EFFECT OF MEROPENEM AND IMICENEM ON MICROBIOCENOSIS AND MORPHOLOGY OF THE SMALL INTESTINE IN RATS

Background. Gut microbiota plays an important role in the human body, antimicrobial drugs intake being one of main factors affecting composition. Antibiotics suppress normal intestinal microflora allowing for growth and development pathogenic flora. Objective. To study effect meropenem imicenem on microbiocenosis morphology small intestine rats. Material methods. In experiment rats, we analysed large after intraperitoneal administration meropenem, imicinem 0.9% NaCl, as well examined samples intestine. Results. a comparative analysis control group with groups, there has been noted decrease number anaerobes (8.6±0.14, p<0.05) compared (9.4±0.22, p<0 .05) (9.4±0.40, p<0.05); bifidobacteria decreased (8.1±0.16, contrast to (9.2±0.25, (9.2±0.41, p<0.05). When (3.8±0.44, p<0.05), (4.9±0.20, led greater spore-forming anaerobes. animals group, histostructure jejunal mucosa was similar while inflammatory changes stroma villi were observed. Conclusions. carbapenem activity, it determined that these antibiotics both have significant affect mucous wall These should be taken into account by clinicians order improve effectiveness safety antibiotic therapy.